Sildenafil Citrate sold as Viagra, acts by inhibiting GMP specific phosphodiesterase type 5, an enzyme that regulates blood flow in the penis. Since becoming available in 1998, Sildenafil has been the prime treatment for erectile dysfunction. Its primary competitors on the market are Tadalafil (Cialis) and Vardenafil (Levitra).
The mechanism of action of Sildenafil Citrate involves the release of nitric oxide in the corpus cavernous area of the penis. Nitric oxide binds to the receptors of the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation, resulting in increased inflow of blood and an erection.
It is best to understand that with the use of Viagra, you do not get an instant erection. In order to get an erection and for the Viagra to work, you must be aroused. After taking Viagra, the results can be seen in about 30 minutes to 1 hour as it works differently in individuals. For some men, it works in as little as 14 minutes. Normally the lasting period for Viagra is 4 hours.
After sexual intercourse, your erection will go away. In the case that your erection lasts for 4 hours or longer, you must consult a doctor immediately as this may harm your penis. In order to get quick results, it is advisable to take Viagra on an empty stomach or after eating a low-fat meal. If taken with a high-fat meal, there may be a delay in absorption of Sildenafil and the peak effect might be reduced slightly as the plasma concentration will be lowered.
Like with all medication, Viagra works the first or second time for most men. But for some men this might not be the case. So if Viagra does not work for you, don’t give up on it. Try taking it again. Keep in mind that Viagra can be taken as often as once a day, every day. If you still do not get results, talk to your doctor. Often a dose adjustment can make all the difference.
